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Frontiers | Design, synthesis, and evaluation of the novel ozagrel

The antiplatelet aggregation activity of the target compounds was evaluated against ADP- and AA-induced platelet aggregation. In other words, different concentrations of the target compound solution and POC (Zhang J. et al., 2021) (10 μL) were added to the plasma at 37°C for 5 min. Then, platelets were stimulated with ADP (10 μM, 30 μL) or ...

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Potent antiplatelet aggregation, anticoagulant and antioxidant …

The antiplatelet effect was evaluated using the turbidimetric method to determine the percentage inhibition (%I), the area under aggregation curve (AUC) and the aggregation velocity (slope). Prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) were measured to assess the inhibitory effect on blood coagulation.

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Current and Novel Antiplatelet Therapies for the Treatment of

The currently available antiplatelet drugs act by preventing the formation of secondary messengers (COX-1 inhibitor), by interacting with intracellular signaling pathways (PDE inhibitors and the PGI2 analogue), by blocking membrane receptors (P2Y12 receptor antagonists and the PAR1 antagonist), or by inhibiting platelet aggregation (GPIIbIIIa ...

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Antiplatelet Resistance: A Review of Concepts, Mechanisms, and

Aspirin reduces platelet activation and aggregation by irreversibly inhibiting the enzyme cyclooxygenase 1 (COX‐1), which in turn inhibits the release of thromboxane A2. 11 Clopidogrel works by irreversible binding of its active metabolite to the P2Y 12 class of adenosine diphosphate (ADP) receptors on platelets. 12 Resistance to aspirin andr clopidogrel has been known for >3 …

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Efficacy, Safety, and Role of Antiplatelet Drugs in the …

Antiplatelet therapy reduces the risk of thrombosis and its consequences, including death and myocardial infarction (MI). Platelet activation and aggregation in response to endothelial injury is a crucial part of the pathophysiology of ACS, and various antiplatelet therapies target different platelet receptors . Antiplatelet medications are ...

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Antiplatelet Drugs: Types, Uses & Side Effects

Antiplatelets interfere with the process of platelets binding together. Anticoagulants, also called blood thinners, interfere with proteins in your blood that are involved with clotting. …

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Anti-platelet therapy: phosphodiesterase inhibitors

Dipyridamole inhibits platelet aggregation in whole blood, as assessed by impedance aggregometry, but not in platelet-rich plasma both in vitro and ex vivo, by blocking the reuptake of adenosine [72, 73]. A stronger antiplatelet effect of dipyridamole in whole blood than in plasma was confirmed using different laboratory methods [74–77].

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Dissolvable polymeric microneedles loaded with aspirin for antiplatelet

Aspirin has significantly reduced morbidity and mortality related to coronary artery disease and is considered as the most cost-effective drug for secondary prevention of coronary artery disease [1].Aspirin is a first-line antiplatelet aggregation drug widely recognized for all types of platelet-dependent thrombotic vessel occlusion [2].Aspirin is a non-selective …

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Phenolic Bioactives as Antiplatelet Aggregation Factors: The …

It has been shown that phenolic compounds have antiplatelet aggregation abilities and a positive impact in the management of CVD, exerting prominent antioxidant, anti-inflammatory, antitumor, cardioprotective, antihyperglycemic, and antimicrobial effects. Thus, this review is intended to address the antiplatelet activity of phenolic compounds ...

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Use of Intravenous Antiplatelet Agents (Cangrelor and GPIIb/IIIa

GPIIb/IIIa inhibitors provide rapid and nearly complete platelet aggregation inhibition, overcoming the delayed and poor platelet inhibition induced by a clopidogrel loading dose. 29 The benefits of pretreatment with GPIIb/IIIa inhibitors were noted in high-risk patients in early clinical trials that showed a significant reduction in MI and ...

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Antiplatelet Drugs

Currently available antiplatelet drugs interfere with one or more steps in the process of platelet release and aggregation 2 and produce a measurable reduction in the risk of thrombosis that cannot be dissociated from an increased risk of bleeding. 3

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Platelet aggregation pathway

Platelet activation and coagulation normally do not occur in an intact blood vessel. After blood vessel wall injury, platelet plug formation is initiated by the adherence of the platelets to subendothelial collagen [1,2].In high shear arterial blood, platelets are first slowed down from their blood flow velocity by interacting with the collagen-bound von Willebrand factor and are …

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List of Platelet aggregation inhibitors

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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List of Platelet Aggregation Inhibition Medications

Platelet Aggregation Inhibitors decrease platelet aggregation and inhibit thrombus formation. They are effective in the arterial circulation, where anticoagulants have little effect. They are widely …

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Platelet aggregometry assay for evaluating the effects of platelet

Generally, the higher the concentration of the antiplatelet agent in the aggregometer cuvette, the lower the platelet aggregation curve recorded by the aggregometer detector of the LTA assay, indicating the inhibitory effect of the antiplatelet agent on platelet aggregation as a percentage of inhibition in relation to the baseline aggregation ...

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Platinum-cerium bimetallic nano-raspberry for

In summary, we successfully designed a cell inhibition and antiplatelet aggregation synergistic strategy for atherosclerosis attenuation based on DPTP NRs. Depending on the unique raspberry shaped morphology and its rough surface, the molecule pay-load and ROS-scavenging capacity were elevated notably. The as-prepared DPTP NRs possessed ...

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Antiplatelet drugs

Antiplatelet drugs are intended to prevent and/or reverse platelet aggregation in arterial thrombosis, most prominently in myocardial infarction and ischaemic stroke. Platelets aggregate as haemostatic plugs at the site of vascular injury, …

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Antiplatelet Drugs

Antiplatelet drugs are primarily directed against platelets and inhibit platelet activation by a number of different mechanisms. They are used for the prevention and treatment of thrombotic processes, especially in the arterial vascular system. ... aggregation, and thrombus formation on subendothelial surface at an injured blood vessel. After ...

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Novel Antiplatelet Therapies for Atherothrombotic Diseases

Antiplatelet therapies are an essential tool to reduce the risk of developing clinically apparent atherothrombotic disease and are a mainstay in the therapy of patients who have established cardiovascular, cerebrovascular, and peripheral artery disease. Strategies to intensify antiplatelet regimens are limited by concomitant increases in clinically significant bleeding. The …

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Antiplatelet Agents for the Treatment and Prevention of Coronary

Clinical Pharmacology of Antiplatelet Drugs. Multiple pathways contribute to platelet activation and aggregation, and although pharmacological interference with these pathways reduces the risk of atherothrombotic complications, it is also associated with an increased risk of bleeding ().It is important to emphasize that the thromboxane (TX) A 2-, adenosine diphosphate (ADP)-, and …

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Not all (N)SAID and done: Effects of nonsteroidal …

Aspirin interferes with platelet activation, aggregation, and secretion by inhibiting the production of TxA 2.24, 25 Aspirin has also been shown to stimulate the production of the platelet inhibitor nitric oxide (NO) in vitro and in vivo, which may contribute to its antiplatelet activity.26 Aspirin impairs α granule secretion and VWF binding ...

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Antiplatelet strategies: past, present, and future

Antiplatelet therapy plays a critical role in the prevention and treatment of major cardiovascular diseases triggered by thrombosis. Since the 1900s, significant progress in reducing morbidity and death caused by cardiovascular diseases has been made. However, despite the development and approval of drugs that specifically target the platelet, including inhibitors for …

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Antiplatelet drugs

Antiplatelet drugs are intended to prevent and/or reverse platelet aggregation in arterial thrombosis, most prominently in myocardial infarction and ischaemic stroke. Platelets aggregate as haemostatic plugs at the site of vascular injury, whereby bleeding is limited or arrested in advance of plasma coagulation ( Figure 1 ).

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Antiplatelet aggregation activity of diterpene alkaloids from …

3.3.. Comparison of in vitro antiplatelet activities of atisine-type alkaloids with those of ginkgolide B and aspirinA comparison of the inhibitory effects of atisine-type alkaloids, ginkgolide B and aspirin on PAF, arachidonic acid and ADP-induced platelet aggregation is shown in Table 1.Of the 14 test compounds, 12 selectively inhibited platelet aggregation induced by PAF.

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Antiplatelet Agents for the Treatment and Prevention …

Antiplatelet drugs provide first-line antithrombotic therapy for the management of acute ischemic syndromes (both coronary and cerebrovascular) and for the prevention of their recurrence.

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Nursing Pharmacology: Anticoagulants & Antiplatelets

Platelet aggregation inhibitors/antiplatelets - clopidogrel, abciximab. Platelet aggregation inhibitors are a class of drugs that decrease platelet aggregation and inhibit thrombus formation. Platelet aggregation is the clumping together of platelets in the blood and is part of the sequence of events leading to the formation of a thrombus or clot.

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Current concepts and novel targets for antiplatelet therapy

Antiplatelet therapy improves prognosis in patients with cardiovascular disease. Bleeding is a major complication of antiplatelet therapy and is associated with an increased risk of death.

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Antiplatelet Medications

Thromboxane A2 works by inducing platelet aggregation and vasoconstriction, and COX-1 mediates its production, while PGI2 works by inhibiting platelet aggregation, induces …

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List of Antiplatelet agents

Antiplatelet agents are medicines that reduce the ability of platelets to stick together (called platelet aggregation) and inhibit the formation of blood clots. Antiplatelet agents play a major …

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Antiplatelet Agents Have a Distinct Efficacy on Platelet Aggregation

CD62P surface exposure was evaluated by flow cytometry. Aggregate organizations were analyzed by scanning electron microscopy. All the strains tested induced a strong platelet aggregation. Antiplatelet drugs showed distinct effects depending on the bacterial species involved with different magnitude between strains of the same species.

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